Not recommended for children under 12 years.

The duration of treatment should be kept to a minimum, although dependence and tolerance are not generally a problem when morphine is used legitimately in patients with opioid-sensitive pain. The patient should be specifically monitored for pain, sedation and respiratory rate during the first few hours of treatment to ensure that the dosage regimen is suitable. Dosages may vary depending on the loading dose, the tolerance and condition of the patient, and whether a background infusion of morphine sulfate is being given. The loading dose used will depend upon the patient's diagnosis and conditions.Īn initial demand dose of 1mg Morphine Sulfate Solution for Injection with a lockout period of 5 to 10 minutes is recommended. Loading doses of typically between 1mg and 10mg (maximum 15mg) of Morphine Sulfate Solution for Injection may be given by intravenous infusion over four or five minutes. Dosage should be based on the severity of the pain and the response and opiate tolerance of the patient. There is a considerable variation in analgesic requirements among patients and therefore individualised treatment strategies are required. The specific department or unit protocols must be covered to ensure aseptic transfer of the contents of the vial to the PCA system. Patient selection for the use of PCA must ensure that the patient is capable of understanding and following the instructions of the medical/nursing staff. PCA, which permits adjustment of dosage according to the patient's individual needs, must only be carried out in departments and by staff who are trained and have experience of the system. Morphine Sulfate Solution for Injection is formulated for use by the intravenous route in Patient Controlled Analgesia (PCA) systems. Prior to starting treatment with opioids, a discussion should be held with patients to put in place a strategy for ending treatment with morphine sulfate in order to minimise the risk of addiction and drug withdrawal syndrome (see section 4.4).

Antidote for morphine sulfate